Paul Weitz (“American Pie”) is directing the film, which is based on the bestselling 12-book children’s series by Darren Shan, saysVariety.

Reilly will play a vampire who drafts a 14-year-old to serve as his assistant. The youth is turned into a half-vampire and becomes the catalyst in a battle between vampires and the rival Vampanese. Hayek will play Madame Truska, the bearded lady.